图书简介
Molecular Biology of B Cells, Third Edition provides a comprehensive reference on how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. The book offers an integrated view of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. This new edition provides updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, and more. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, this updated release is a definitive resource, vital for researchers across molecular biology, immunology, and genetics.
1. The Structure and Regulation of the Immunoglobulin Loci Joseph S. Lucas, Cornelis Murre, Ann J. Feeney and Roy Riblet 2. The Mechanism, Regulation and Evolution of V(D)J Recombination David G. Schatz, Yiwen Zhang, Jianxiong Xiao, Shan Zha, Yu Zhang and Frederick W. Alt 3. The Origin of V(D)J Diversification Ellen Hsu and Susanna M. Lewis 4. The Variable Lymphocyte Receptor B System of the Jawless Vertebrates Thomas Boehm, Max D. Cooper, Masayuki Hirano, Sabyasachi Das, Ryo Morimoto and Jonathan P. Rast 5. Structure and Signalling Function of the B-Cell Antigen Receptor and Its Coreceptors Michael Reth, Kathrin Klasener, Lars Nitschke and Michael R. Gold 6. Fc Receptors Jeffrey V. Ravetch and Stylianos Bournazos 7. Transcriptional Regulation of Early B-Cell Development Ashley P. Ng, Rhiannon Morris and Stephen L. Nutt 8. Relationship between B-Cell Populations, Development and Function of B-Cell Subsets Eva Piano Mortari and Rita Carsetti 9. B-Cell Development to Immunity and Tolerance Fritz Melchers, Mir-Farzin Mashreghi and Peter K. Jani 10. The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology Fabienne Mackay and Jennifer L. Gommerman 11. Mechanism and Regulation of Immunoglobulin Class Switch Recombination Fei-Long Meng, Lekha Nair, Keith C. Fernandez, Uttiya Basu and Jayanta Chaudhuri 12. Somatic Hypermutation Jana Ridani, Philip Barbulescu, Alberto Martin and Javier M. Di Noia 13. Molecular Mechanism of Activation-Induced Cytidine Deaminase Nasim A. Begum, Maki Kobayashi, Hitoshi Nagaoka and Tasuku Honjo 14. Molecular Pathogenesis of B-Cell Lymphomas Laura Pasqualucci, Pantaleo De Simone and Riccardo Dalla-Favera 15. Human Immunodeficiencies Caused by Inborn Errors of B-Cell Development or Function Stuart G. Tangye, Jean-Laurent Casanova and Cindy S. Ma 16. Memory B Cells and Plasma Cells Mairi Anne McGrath, Florian Weisel, Andreas Radbruch and Mark Shlomchik 17. Homoeostatic Versus Pathogenic Autoantibodies: Origin, Structure and Effector Functions Yemil Atisha-Fregoso, Rita Pozovskiy, Shabirul Haque, Manami Watanabe, Yong-Rui Zou and Betty Diamond 18. Anti-Tumour Necrosis Factor and New Paradigms for Therapies Using Antibodies Sergei A. Nedospasov, Marina S. Drutskaya and Andrey A. Kruglov 19. Therapeutic Targeting of B Cells and Plasma Cells with a Focus on Multiple Sclerosis and Other Autoimmune Conditions Andreia C. Lino and Thomas Dorner 20. IMGT Immunoglobulin Repertoire Analysis and Antibody Humanization Marie-Paule Lefranc 21. Mucosal Immunity to Bacteria and Immunoglobulin A Synthesis Andrew J. Macpherson, Tim Rollenkse, Lucia M. Kato and Sidonia Fagarasan 22. B-Cell Metabolism Julia Jellusova
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