Multi-Component Reactions in Molecular Diversity

Multi-Component Reactions in Molecular Diversity

分子多样化的多组分反应
生物化学

原价：

￥ 2046.25

售价：

优惠

平台大促低至8折优惠

发货周期：预计3-5周发货

作者

Jean-Philippe Goddard

出版社

Wiley-ISTE

出版时间

2020年03月04日

装帧

精装

ＩＳＢＮ

9781786305114

复制

页码

198

开本

9.30 x 6.30 x 0.60

语种

英文

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暂无评分

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While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.

Chapter 1. Organometallic Multicomponent Reactions 1 Nuno MONTEIRO 1.1. Introduction 1 1.2. Multicomponent reactions: concept and applications 2 1.2.1. Concept and correlation with the principles of green chemistry 2 1.2.2. Origins and areas of application 5 1.3. Merging multicomponent and organometallic transformations 9 1.3.1. History: the predominant role of palladium 9 1.3.2. Contribution of catalysis in multicomponent reactions 12 1.3.3. Multicomponent catalytic reactions: design and applications 24 1.4. Conclusion 48 1.5. References 49 Chapter 2. Use of 1,3-Dicarbonyl Derivatives in Stereoselective Domino and Multicomponent Reactions 59 Damien BONNE, Thierry CONSTANTIEUX, Yoann COQUEREL and Jean RODRIGUEZ 2.1. Introduction 59 2.2. Domino reactions 61 2.2.1. Diastereoselective domino reactions 61 2.2.2. Enantioselective domino-domino reactions 69 2.3. Multicomponent reactions 81 2.3.1. Diastereoselective multicomponent reactions 81 2.3.2. Enantioselective multicomponent reactions 92 2.4. Conclusion 104 2.5. References 105 Chapter 3. Multicomponent Radical Processes: Recent Developments 121 Yannick LANDAIS 3.1. Polar effects: electrophilic and nucleophilic radical scales 122 3.2. Multicomponent radical reactions 123 3.2.1. Three-component radical reactions: radical additions to olefins 123 3.2.2. Three-component radical reactions: radical additions on imines 135 3.2.3. Four- and five-component radical reactions: carbonylation reactions 140 3.3. Multi-component radical-ionic reactions 145 3.3.1. Multi-component radical-anionic reactions 145 3.3.2. Multi-component radical-cationic reactions 157 3.4. Sequential multicomponent radical reactions 160 3.4.1. Organometallic-radical sequential reactions 160 3.4.2. Ugi reactions: radical reactions 161 3.4.3. Passerini reaction using radicals 163 3.5. Multicomponent reactions by photoredox catalysis 166 3.6. Conclusion 172 3.7. References 172 List of Authors 183 Index 185

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