图书简介
Umbilical cord blood, previously discarded after birth, has emerged over recent years as an alternative source of hematopoietic stem cells for hematological reconstitution, mainly for leukemia patients, as well as for some hematological deficiencies and bone marrow failures. In recent years, it has become increasingly clear that cord blood, as well as the surrounding tissue of the umbilical cord, contain additional stem cells which have been shown to be of great potential for regenerative medicine. Importantly, cord blood is abundant, it can be banked and shipped with ease, and thus has an indisputable potential for future medicines and regenerative therapies. Driven by a massive interest for regenerative medicine and alternative yet ethically acceptable stem cell sources, the scientific literature on umbilical cord and cord blood stem cells has increased tremendously.
This book provides a consolidated, up-to-date overview of basic research on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently described stem and precursor cells of not yet fully elucidated potential. It also takes an in-depth look at basic and translational research efforts with stem cells from the umbilical cord in academic institutions and biotech companies. Suitable for use as a primer and reference book by medical fellows and researchers entering the research fields of stem cell biology and regenerative medicine, it can also be used by students (undergraduate and graduate) as a starting point for read-up on the literature on stem cells and their potential and applications, or as a teaching tool in graduate schools for biologists, particularly for students wanting to enter the emerging field of stem cell biology.
Key Features
• Covers several paradigms of non-embryonic stem cell biology and the potential of stem cells for regenerative medicine
• One of the first book with the same in-depth focus on all the stem cells within the umbilical cord
• Presents an overview of an abundant scientific literature on stem cell research
• Serves as a primer and reference book for medical fellows and researchers, and as a teaching tool in graduate schools
Hematopoietic Stem Cells (HSC): Hematopoietic Stem and Progenitor Cells in Umbilical Cord Blood (C Lengerke & S Kadereit); Cord Blood and Cancer (M J Laughlin & P Weitzel); HSC and Asymmetric Division (A Görgens & B Giebel); Expansion of Cord Blood HSC (I McNiece); Mesenchymal Stem Cells (MSC): Biology of MSC (M Pittenger); MSC and Orthopedic Regeneration (J C Reichert et al.); MSC and Neurological Regeneration (G Udolph et al.); Immune Properties of MSC (M Pittenger & K LeBlanc); Expansion of MSC for Clinical Use (M Prat-Lepesant et al.); Other Stem and Progenitor Cells in Cord Blood and Surrounding Tissue: The Unrestricted Somatic Stem Cell (USSC) (G Kögler et al.); Endothelial Precursor Cells (EPC) (M Finney & M Laughlin); Stem Cells of the Cord and Wharton Jelly (M Weiss & K Seshareddy); Future Outlook: Banking of Cord Blood (S Y Ong & W Hwang); Commercialization of Cord Blood (V Tanavde).
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