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1. Principles of basic and clinical endocrinology; 1.1 Lynn Loriaux: Endocrine Practice Fundamentals; 1.2 John W. Funder: Hormones and receptors: fundamental considerations; 1.3 Ken Siddle and Gemma Brierley: Molecular aspects of hormonal regulation; 1.4 Janine A. Danks and Samantha J. Richardson: Endocrinology and evolution: lessons from comparative endocrinology; 1.5 James Gibney, Indi Banerjee, and Ken Ho: Hormones Across the Lifespan; 1.6 Brian Keevil, Peter Trainer, and William Drake: Pituitary assessment strategy; 1.7 Simon Pearce and Catherine Owen: Endocrine autoimmunity; 1.8 Jerome Bertherat, Anne Jouinot, and Fideline Bonnet-Serrano: Common Features of Endocrine Tumours; 1.9 Trevor Cole: Genetic Aspects of Endocrine Disease; 1.10 George Mastorakos, Markella Nezi, Djuro Macut, and Maria Papagianni: Environmental Influences on Endocrine Disease; 1.11 Georg Brabant and H. Oster: Endocrinology, sleep and circadian rhythms; 1.12 Richard Ross: Principles of Hormone replacement; 1.13 Jonathan Valabhji and Rochan Agha-Jaffar: Prevention in endocrinology; 2. Pituitary and hypothalamic diseases; 2.1 John Morris: Functional anatomy of the hypothalamus and pituitary; 2.2 Stephen G. Ball: The neurohypophysis; 2.3 Aetiology, pathogenesis, and management of disease of the pituitary; 2.3.1 Mehul T. Dattani and Louise C. Gregory: Development of the pituitary and genetic forms of hypopituitarism; 2.3.2 Shlomo Melmed: Molecular pathogenesis of pituitary tumours; 2.3.3 Luis Syro, Kalman Kovacs, and Fabio Rotondo: Histopathology of pituitary tumours; 2.3.4 Jean-Francois Bonneville, Sonia Nagi, and Iulia Potorac: Imaging of the pituitary; 2.3.5 Miles J. Levy, Ragini Bhake, and Narendra Reddy: Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes; 2.3.6 Jens Jorgensen: Adult growth hormone deficiency; 2.3.7 Edward R. Laws Jr, David L. Penn, and Caroline S. Repetti: Surgery of pituitary tumours; 2.3.8 Naomi Fersht and Francesca Solda: Pituitary radiotherapy; 2.3.9 Nicholas Tritos and Anne Klibanski: Prolactinomas and hyperprolactinaemia (including macroprolactinaemia); 2.3.10 John Wass, Peter J. Trainer, and Marta Korbonits: Acromegaly; 2.3.11 Nienke Biermasz and Wouter R. van Furth: Clinically nonfunctioning pituitary tumours and gonadotropinomas; 2.3.12 Mark Gurnell, Olympia Koulouri, and Waiel Bashari: Thyrotropinomas; 2.3.13 Ann McCormack: Pituitary carcinoma; 2.3.14 Niki Karavitaki, Shu Teng Chai, and Shahzada Ahmed: Pituitary incidentalomas; 2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus; 2.4.1 Mehul Dattani, Hoong-Wei Gan, and Manuela Cerbone: Hypothalamic dysfunction (hypothalamic syndromes); 2.4.2 Niki Karavitaki: Craniopharyngiomas; 2.4.3 Jurgen Honegger, Ulrike Ernemann, and Rudi Beschorner: Perisellar tumours including cysts, hamartomas, and vascular tumours; 2.4.4 Mark E. Molitch and Jelena Kravarusic: Lymphocytic hypophysitis and other inflammatory conditions of the pituitary; 2.5 Susan M Webb, Anna Aulinas, Cristina Colom, and Jose Barahona: Pineal physiology and pathophysiology, including pineal tumours; 3. The Thyroid; 3.1 Evaluation of the thyroid patient; 3.1.1 Robert Volpe and Clark Sawin: The history and iconography relating to the thyroid gland; 3.1.2 W. Edward Visser: Biosynthesis, transport, metabolism, and actions of thyroid hormones; 3.1.3 Inge Bulow Pedersen and Stig Andersen: Clinical assessment of the thyroid patient; 3.1.4 Ulla Feldt-Rasmussen: Thyroid function tests and the effects of drugs; 3.1.5 Robin P. Peeters and Anita Boelen: Nonthyroidal illness syndrome; 3.1.6 Steen Bonnema and Laszlo Hegedus: Thyroid imaging: nuclear medicine techniques; 3.1.7 Laszlo Hegedus and Finn N. Bennedbaek: Thyroid imaging: nonisotopic techniques; 3.1.8 Mark P. J. Vanderpump: Epidemiology of thyroid disease and swelling; 3.2 Aetiology of thyroid disorders; 3.2.1 Terry Davies, Francesca Menconi, and Yaron Tomer: The complex genetics of thyroid disease; 3.2.2 Josef Kohrle: Environmental factors; 3.2.3 Michael B. Zimmermann: Iodine deficiency disorders; 3.2.4 Shunichi Yamashita, Furio Pacini, and Rossella Elisei: Radiation-induced thyroid disease; 3.2.5 Anthony P. Weetman: Autoimmune thyroid disease; 3.2.6 Elizabeth N. Pearce and Alan Farwell: Thyroiditis; 3.3 Thyrotoxicosis and related disorders; 3.3.1 Claudio Marcocci and Filomena Cetani: Clinical assessment and systemic manifestations of thyrotoxicosis; 3.3.2 Annie W. C. Kung and C.L. Cheung: Thyrotoxic periodic paralysis; 3.3.3 Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska: Thyrotoxic storm; 3.3.4 Simon Pearce: Subclinical hyperthyroidism; 3.3.5 Francesco Latrofa and Paolo Vitti: Causes and laboratory investigations of thyrotoxicosis; 3.3.6 Luigi Bartalena: Anti-thyroid drug treatment for thyrotoxicosis; 3.3.7 Markus Luster and Michael Lassmann: Radio-iodine treatment of hyperthyroidism; 3.3.8 Nancy Dugal Perrier, Orlo Clark, and Sarah B. Fisher: Surgery for thyrotoxicosis; 3.3.9 Jacques Orgiazzi: Management of Graves hyperthyroidism; 3.3.10 Wilmar M. Wiersinga: Graves orbitopathy and dermopathy; 3.3.11 Dagmar Fuhrer and Holger Jaschke: Management of toxic multinodular goitre and toxic adenoma; 3.3.12 Wilmar M. Wiersinga: Management of thyrotoxicosis without hyperthyroidism; 3.4 Hypothyroidism; 3.4.1 Massimo Tonacchera and Luca Chiovato: Clinical assessment and systemic manifestations of hypothyroidism; 3.4.2 Ferruccio Santini: Causes and laboratory investigation of hypothyroidism; 3.4.3 Leonard Wartofsky, Dorina Ylli, and Joanna Klubo-Gwiezdzinska: Myxoedema coma; 3.4.4 Bijay Vaidya and Chantal Daumerie: Subclinical hypothyroidism; 3.4.5 Mark Gurnell, Carla Moran, and V. K. Chatterjee: Syndromes of Resistance to Thyroid Hormone; 3.4.6 Birte Nygaard: Treatment of hypothyroidism; 3.5 Thyroid lumps; 3.5.1 Dagmar Fuhrer and Holger Jaschke: Pathogenesis of nontoxic goitre; 3.5.2 Hans Graf and Gilberto Paz Filho: Management of nontoxic multinodular goitre; 3.5.3 Laszlo Hegedus and Finn N. Bennedbaek: Management of the single thyroid nodule; 3.5.4 Massimo Santoro, Barbara Jarzab, Jolanta Krajewska, and Dagmara Rusinek: Pathogenesis of thyroid cancer; 3.5.5 Fulvio Basolo and Clara Ugolini: Pathology of thyroid cancer; 3.5.6 Corin Badiu and Ruxandra Dobrescu: Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma; 3.5.7 Friedhelm Raue and Karin Frank-Raue: Medullary thyroid carcinoma; 4. Parathyroid, calcium, and bone metabolism; 4.1 David Goltzman and Geoffrey N. Hendy: Parathyroid anatomy, hormone synthesis, secretion, action, and receptors; 4.2 Claudio Marcocci, Federica Saponaro, and Filomena Cetani: Hypercalcaemia; 4.3 John P. Bilezikian: Primary hyperparathyroidism; 4.4 Dolores Shoback and Muriel Babey: Familial Hypocalciuric Hypercalcemia Types 1-3 and Neonatal Severe Primary Hyperparathyroidism; 4.5 Rajesh Thakker, Bart Clarke, and Fadil M. Hannan: Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism; 4.6 Paul D. Miller and Michael Pazianas: Bones and the Kidney-The Practical Conundrum: Distinguishing Between Osteoporosis and the Bone Diseases that Accompany Chronic Renal Failure; 4.7 Laleh Ardeshirpour, Thomas O. Carpenter, and Cemre Robinson: Hypercalcaemic and hypocalcaemic syndromes in children; 4.8 Richard Eastell: Osteoporosis; 4.9 Graham R. Williams, J. H. Duncan Bassett, Bernard Freudenthal, and Laura M. Watts: Thyroid disorders and bone disease; 4.10 Socrates E. Papapoulos: Paget s disease of bone; 4.11 Michael P. Whyte: Rickets and osteomalacia (acquired and heritable forms); 4.12 Gherardo Mazziotti, Ernesto Canalis, and John P. Bilezikian: Glucocorticoid-induced osteoporosis; 5. The adrenal gland and endocrine hypertension; 5.1 Peter Guest: Adrenal imaging; 5.2 Fausto Palazzo and Radu Mihai: Adrenal surgery; 5.3 Irina Bancos, Massimo Terzolo, and Wiebke Arlt: Adrenal incidentaloma; 5.4 Jerome Bertherat, Rossella Libe, and Anne Jouinot: Adrenocortical cancer; 5.5.1 Eamonn R. Maher and Ruth T Casey: Genetics of phaeochromocytomas, paragangliomas, and neuroblastoma; 5.5.2 Henri Timmers: Management of phaeochromocytoma and paragagnlioma; 5.6.1 Maria Christina Zennaro, Fabio Fernandes-Rosa, and Sheerazed Boulkroun: Genetics of primary aldosteronism and other steroid-related causes of endocrine hypertension; 5.6.2 Morris Brown and Will Drake: Management of primary aldosteronism; 5.7 John Newell-Price: Cushing s syndrome; 5.8.1 Li Chan and Shwetha Ramachandrappa: Genetics of Adrenal Insufficiency; 5.8.2 Wiebke Arlt: Management of Adrenal Insufficiency; 5.9.1 Nils P. Krone: Genetics of congenital adrenal hyperplasia; 5.9.2 Richard J. Auchus: Modern management of congenital adrenal hyperplasia and prospects for the future; 6. Neuroendocrine tumours and genetic disorders; 6.1 Guido Rindi and Rajaventhan Srirajaskanthan: Overview and Pathophysiology of Neuroendocrine Neoplasms; 6.2 Whaljit Dhillo and Paul Bech: Neuroendocrine tumour markers; 6.3 Rajaventhan Srirajaskanthan, Martyn E. Caplin, and Dominique Clement: Carcinoid syndrome ; 6.4.1 Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor: Lung neuroendocrine tumours; 6.4.2 Juan W. Valle, Kok Haw Jonathan Lim, and Wasat Mansoor: Non-functioning pancreatic neuroendocrine tumours; 6.5 Christos Toumpanakis and Martyn E. Caplin: Gastrinoma; 6.6 Ashley Grossman and Ingrid YF Mak: Insulinoma and hypoglycaemia; 6.7 Karim Meeran: Glucagonoma; 6.8 Alia Munir: Vasointestinal Polypeptide Secreting Tumours; 6.9 John Wass: Somatostatinoma; 6.10 Prakash Manoharan: Imaging neuroendocrine tumours of the gastrointestinal tract/gastroenteropancreatic neuroendocrine tumours (GEP-NET); 6.11 Rajesh V. Thakker: Multiple endocrine neoplasia type 1; 6.12 Electron Kebebew, Douglas Wiseman, and Mustapha El Lakis: Multiple endocrine neoplasia type 2a and 2b; 6.13 Eamonn R. Maher and Ruth T. Casey: Familial syndromes and genetic causes of paraganglioma and phaeochromocytoma ; 6.14 Constantine A. Stratakis and Fabio Faucz: Carney s complex; 6.15 Michael A. Levine and Steven A. Lietman: Molecular and Clinical Characteristics Of the McCune-Albright Syndrome; 6.16 Charis Eng, Lamis Yehia, and Shreya Malhotra: Cowden syndrome; 7. Growth and development during childhood and adolescence; 7.1 Growth and its Disorders; 7.1.1 Gary Butler: Recognising Normal and Disordered Growth; 7.1.2 Alexander A. L. Jorge, Fernanda A. Correa, and Renata C. Scalco: Disorders of the GH-IGF Axis; 7.1.3 Anita Hokken-Koelega: Short stature in children born small for gestational age; 7.1.4 Steve Chernausek and Minu George: Growth Disorders with no defined aetiology; 7.1.5 Lars Savendahl and Emelie Benji: Tall Stature; 7.2 Sex Development; 7.2.1 Olaf Hiort and Ralf Werner: Sex Determination and Differentiation; 7.2.2 S. Faisal Ahmed and Salma R. Ali: Disorders of Sex Development (DSD) in the newborn; 7.2.3 Alan Rogol and John Fuqua: Recognising Normal and Disordered Pubertal Development; 7.2.4 Alan Rogol and John Fuqua: Pubertal Delay and Hypogonadism; 7.2.5 Julianne Leger and Jean-Claude Carel: Precocious Puberty; 7.3 Helena Gleeson and Rohana Wright: Transition In Endocrinology; 8. Female endocrinology and pregnancy; 8.1 Normal female endocrinology and ovarian disorders; 8.1.1 Chris McCartney and John Marshall: Neuroendocrinology of reproduction: the role of hypothalamus and pituitary; 8.1.2 Terhi Piltonen and Juha Tapanainen: Ovarian and uterine development from fetal life to puberty; 8.1.3 Gurkan Bozdag, Baris Ata, and Engin Turkgeldi: Menstrual cycle and ovulation; 8.2 Evaluation of the female patient with suspected reproductive endocrine disorders; 8.2.1 Channa Jayasena, Steve Franks, and Rachel Roberts: Clinical evaluation of patient with suspected reproductive endocrine disorders; 8.2.2 Daniel Dumesic and Zain Al-Safi: Laboratory evaluation; 8.3 Reproductive endocrine disorders; 8.3.1 Sarah L. Berga: Disorders of gonadotrophin secreton; 8.3.2 Julian R. E. Davis and Agnieszka Swiecicka: Hyperprolactinaemia; 8.3.3 Deepthi Lavu, Radha Indusekhar, and Shaughn O’Brien: Premenstrual syndrome; 8.4 Polycystic ovary syndrome and other androgen excess disorders; 8.4.1 Bulent Yildiz and Sezcan Mumusoglu: Polycystic ovary syndrome: definitions, phenotypes, prevalence and genetics; 8.4.2 R Jeffrey Chang: Polycystic ovary syndrome: reproductive aspects; 8.4.3 David Ehrmann and Susan Sam: Polycystic ovary syndrome: metabolic aspects; 8.4.4 Duarte Pignatelli, Ricardo Azziz, and Bulent Yildiz: Polycystic ovary syndrome: Hirsutism; 8.5 Female hypogonadism and menopause; 8.5.1 Ephia Yasmin and Gerard S. Conway: Female hypogonadism: premature ovarian insufficiency; 8.5.2 Dimitrios G. Goulis, Stavroula A. Paschou, and Panagiotis Anagnostis: Female hypogonadism: Endocrinology of the menopause and hormone replacement therapy; 8.6 Female infertility; 8.6.1 Adam Balen and Susie Jacob: Female Infertility and assisted reproduction; 8.6.2 Kutluk Oktay and Enes Taylan: Female infertility: fertility preservation; 8.7 Hormonal contraception; 8.7.1 Jennifer Chin Bliss Kaneshiro: Hormonal contraception; 8.8 Exogenous factors and female repoductive health; 8.8.1 Alessandra Gambineri and Daniela Ibarra-Gasparini: Exogenous factors and female reproductive health: common extragonadal endocrinopathies affecting reproduction; 8.8.2 Siew Lim, Aya Mousa, Soulmaz Shorakae, and Lisa Moran: Exogenous factors and female reproductive health: nutrition and reproduction; 8.8.3 Evy Diamanti-Kandarakis and Eleni A Kandaraki: Exogenous factors and female reproductive health: envrionment and reproduction; 9. Endocrinology of pregnancy; 9.1 Endocrine disorders of Pregnancy; 9.1.1 Peter Taylor, LDKE Premawardhana, and John Lazarus: General considerations relating to thyroid disease in pregnancy; 9.1.2 Kris Poppe, Flora Veltri, and David Unuane: Management of thyroid disorders before assisted and spontaneous pregnancy; 9.1.3 Tim Korevaar and Robin Peeters: Thyroid disease during pregnancy; 9.1.4 Nobuyuki Amino and Naoko Arata: Management of thyroid disorders after pregnancy; 9.1.5 A. S. Paul van Trotsenburg Nitash and Zwaveling-Soonawala: Thyroid disorders in newborns, infants and children; 9.1.6 Mark Molitch and Wenyu Huang: Pituitary tumours in pregnancy; 9.1.7 Paul Carroll, Niki Karavitaki, and Kirstie Lithgow: Other disorders of the pituitary and hypothalamus in pregnancy; 9.1.8 David Torpy, Michael O’Reilly, and Sunita De Sousa: Adrenal disease in pregnancy; 9.1.9 Jeremy Cox and Stephen Robinson: Endocrine bone disease in pregnancy; 9.1.10 Sandra Lowe: Imaging of endocrine disorders in pregnancy; 10. Male Reproductive Endocrinology; 10.1 Normal male reproductive endocrinology; 10.1.1 Ilpo Huhtaniemi and Jorma Toppari: Endocrine and local regulation of testicular hormone and sperm production; 10.1.2 Dirk Vanderschueren, Leen Antonio, Nari Kim, and Frank Claessens: Sex steroid actions in the Male; 10.2 Evaluation of the male patient with suspected hypogonadism and/or infertility; 10.2.1 Bradley Anawalt: Clinical evaluation; 10.2.2 Jean-Marc Kaufman: Endocrine evaluation; 10.2.3 Jackson Kirkman-Brown and Sarah J Conner: Diagnostic Semen analysis; 10.3 Male reproductive endocrine disorders; 10.3.1 Claus H. Gravholt: Klinefelter s syndrome; 10.3.2 Adult Hypogonadism: Aetiology; 10.3.2.1 Alvin Matsumoto and Radhika Narla: Etiology of Hypogonadism; 10.3.2.2 Giovanni Corona, Mario Maggi, and Giulia Rastrelli: Types of Treatments; 10.3.2.3 Michael Zitzmann: Gonadotrophin induction of spermatogenesis; 10.3.2.4 Shehzad Basaria and Thiago Gagliano-Juca: Male Hypogonadism: Benefits of Testosterone Treatment; 10.3.2.5 Adrian Dobs and Swaytha Yalamanchi: Risks of T Treatment; 10.3.3 Herman J. Tournaye and Biljana Popovic-Todorovic: Management of Idiopathic male infertility; 10.3.4 Mathis Grossmann, B. Yeap, and Gary Wittert: Hypothalamo-pituitary-testicular axis fucntion in systemic diseases and effects of medications; 10.3.5 Vincenzo Rochira, Antonio R. M. Granata, and Cesare Carani: Management of sexual dysfunction; 10.3.6 Stephanie Page and Maritza Farrant: Hormonal male contraception; 10.3.7 Glenn Braunstein: Gynaecomastia; 10.4 Exogenous factors and male reproductive health; 10.4.1 Jorma Toppari: Environmental influences on male reproductive health; 10.4.2 David Handelsman: Androgen Misuse and Abuse; 11. Management of the Transgender Patient; 11.1 Jon Arcelus and Walter Bouman: Introduction to Transgender and Gender Diverse People; 11.2 Daniel Klink: Endocrine Treatment of Transgender Youth; 11.3 Vin Tangpricha and Craig Sineath: Hormone Therapy in transgender women; 11.4 Guy T’Sjoen and Justine Defreyne: Hormone therapy in transgender men; 11.5 Chloe De Roo and Guy T’Sjoen: Fertility Options for Transgender Persons ; 12. Endocrine Responses to Systemic Diseases or Substance Use; 12.1 Endocrinology of systemic disease; 12.1.1 David Henley, Thomas Upton, and Stafford L. Lightman: The endocrine response to stress; 12.1.2 Greet Van den Berghe and Lies Langouche: Endocrinology in the critically ill; 12.1.3 David Johnson, Melissa Nataatmadja, and Yeoungjee Cho: Hormones and the kidney; 12.1.4 Jacob George and Mohammed Eslam: The endocrinology of liver disease; 12.1.5 Steven K. Grinspoon and Takara Stanley: Endocrine abnormalities in HIV infection; 12.1.6 Karen Miller: The endocrinology of anorexia nervosa; 12.2 Endocrine Complications of Substance Misuse ; 12.2.1 Marc Walter and Margit Proescholdt: Endocrinology and alcohol; 12.2.2 Peter Sonksen and Richard Holt: Use and abuse of performance-enhancing hormones in sport; 12.2.3 Ashley Grossman, Eleni Armeni, and Bernard Khoo: Effect of Opioids on Adrenal and Reproductive Endocrinology; 13. Endocrinology of cancer; 13.1 Endocrine Disorders Caused by Cancer or its Treatment; 13.1.1 Thomas Papathomas and Vania Nose: Metastatic Disease in Endocrine Organs; 13.1.2 David W. Ray: Paraneoplastic endocrine syndromes; 13.1.3 Claire Higham and Rob Murray: Long-term endocrine sequelae of cancer therapy; 13.1.4 Carla Moran: Endocrine complications of biological cancer therapies; 13.2 Hormonal therapy for breast and prostatic cancers; 13.2.1 Rob Clarke and Alice Greenhalgh: The breast: lactation and breast cancer as an endocrine disease; 13.2.2 Amna Sheri and Laura Morrison: Endocrine treatment of breast cancer; 13.2.3 Irina A. Vasilevskaya, Matthew J. Schiewer, and Karen E. Knudsen: Hormonal Therapy for Prostate Cancer: Molecular basis of efficacy and therapeutic bypass; 14. Obesity, lipids, and metabolic disorders; 14.1 Obesity; 14.1.1 Anthony Coll: The Physiology of Bodyweight Regulation; 14.1.2 Adrian Bauman: Obesity as a Public Health Problem; 14.1.3 Rachel Batterham and Friedrich Jassil: Medical Complications of Obesity ; 14.1.4 John Wilding and Jonathan Lim: Dietary and Medical Management of Obesity; 14.1.5 Francesco Rubino, Vivian Anastasiou, Luca Ferraro, Dalal Qanaq, and Ghassan Chamseddine: Metabolic Surgery; 14.1.6 Sadaf Farooqi: Assessment of Obesity in Children; 14.1.7 Russell Viner and Billy White: Management of Obesity in Children and Young People; 14.1.8 Nick Finer: Planning obesity care pathways; 14.2 Lipoprotein metabolism and dyslipidaemia; 14.2.1 Bo Angelin and Paolo Parini: Lipoprotein metabolism; 14.2.2 Stefano Romeo, Bo Angelin, and Paolo Parini: Genetic forms of dyslipidaemia; 14.3 Other metabolic disorders; 14.3.1 Khalid Hussain and Sonya Galcheva: Hyperinsulinaemic Hypoglycaemia; 14.3.2 Phillip Gorden and Noemi Malandrino: Autoimmune Hypoglycaemia ; 14.3.3 Robin H. Lachmann: Disorders of carbohydrate metabolism; 14.3.4 Yves Deugnier and Edouard Bardou-Jacquet: Haemochromatosis And Other Inherited Diseases Of Iron Metabolism; 14.3.5 Michael N. Badminton and Danja Schulenburg-Brand: The porphyrias; 15. Diabetes mellitus; 15.1 Introduction to Diabetes Mellitus; 15.1.1 Shanta Persaud and Peter Jones: Physiology of glucose homeostasis; 15.1.2 Stephen Colagiuri and Crystal Man Ying Lee: Classification and diagnosis of diabetes mellitus; 15.2 Aetiopathogenesis and Diagno

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