图书简介
This volume is a compilation of the presentations and discus sions, arranged in a systematic manner, of the fifth symposium on the Search for the Causes of Schizophrenia, held in Guarujal Brazil in April, 2003. The meetings look back on a great tradi tion. The first symposium, held in 1986 on the occasion of the th 600 anniversary of the University of Heidelberg, was our first effort to assemble successful schizophrenia researchers to pre sent and discuss research results in a spirit overcoming meth odological boundaries and disciplines. The result was one of the most interesting and exciting meetings and a proceedings volume published in 1987. Like the present volume it contained the presentations and discussions of the meeting conveying an excellent picture of what was going on in schizophrenia re search at that time and outlining the main future perspectives. Four further symposia followed at an interval of 2 to 3 years each. They were guided by the same principle and characterised by illustrious contributors and a highly stimulating atmosphere. The proceedings volumes, all entitled ’Search for the causes of schizophrenia’ and looking alike, were published by the same publisher. They reflect the considerable progress made in schi zophrenia research since 1986 and have been widely used as a source for information on the most promising research lines and results and as a reference for comprehensive reviews.
List of Contents.- Section 1 - Epidemiology and environment.- Schizophrenia and migration.- Childhood meningitis and adult schizophrenia.- The course and outcome of schizophrenia: toward a new social biology of psychosis.- Psychotic features in the general population.Risk factors for what?.- Discussion: Epidemiology and environment.- Section 2 - Precursors of schizophrenia.- Early developmental abnormalities - risk for what?.- Are there specific risk factors for schizophrenia?.- Risk factors for schizophrenia in adolescents.- Cannabis as a causal factor for psychosis - a review of the evidence.- Discussion: Schizophrenia - diverse etiologies,common pathogenesis.- Section 3 - Pathophysiological mechanisms.- Genetic liability, brain structure and symptoms of schizophrenia.- The hippocampus and schizophrenia.- Neuroimaging studies of auditory verbal hallucinations.- Gender differences in schizophrenia.- Section 4 - Genetics.- Searching for inherited causes for schizophrenia:has progress been made?.- Gene expression in psychotic disorders:dissecting the genetic basis of complex neuropsychiatric disorders.- Brain morphological abnormalities in first-degree relatives of schizophrenic patients.- Genetics of schizophrenia and the impact of neuropsychology.- Human genome and the perspectives for schizophrenia.- Discussion: The genetics of psychosis is the genetics of the speciation of Homo sapiens.- Section 5 — Controversies in schizophrenia.- Criminal and antisocial behaviours and schizophrenia: a neglected topic.- The aetiological continuum of psychosis.- When does structural brain change appear in schizophrenia and is it clinically relevant?.- Schizophrenia: developmental, degenerative or both?.- Schizophrenia as a progressive developmental disorder:the evidence and its implications.- Controversies in schizophrenia research:the ‘continuum’ challenge, heterogeneity vs homogeneity, and lifetime developmental-‘neuroprogressive’ trajectory.- Section 6 — Treatment.- What can psychological treatments say about causes in schizophrenia?.- Intervention in the prepsychotic phase of schizophrenia and related disorders: towards effective and safe strategies for earliest intervention in psychotic disorders.- What can molecular imaging tell us about schizophrenia?.- Schizophrenia: treatment issues in the 21stcentury.
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