图书简介
During the past two decades, research on animal, plant, and microbial toxins has expanded rapidly, and new and exciting information has appeared to clarify both the clinical and therapeutic aspects of intoxication and, even more impor tant, to help us understand more exactly the structure and the mode of action of toxins on a molecular basis. Because of the interdisciplinary nature of toxin research, it is of vital impor tance that workers specializing in its different aspects should make a particular effort to exchange and keep up with new developments in this rapidly-expanding field. This has been one of the main purposes of the series of international meetings that have been held over the past ten years. The increasing interest in the results of toxin research can be explained partly by the growing general preoccupation with pollution and its toxic effects, which means that more and more specialists in other fields are finding it necessary to keep in touch with current research into naturally occurring toxins. The papers in these volumes were presented at the Fourth International Symposium on Animal, Plant and Microbial Toxins, organized by the Inter national Society on Toxinology, held in Tokyo in September, 1974. The editors have decided to include both original reports and review articles, arranged according to disciplines. Editing has been kept to the minimum necessary for adequate comprehension of the materials.
I. Biochemistry (Animals).- Biosynthesis of Erabutoxins in the Sea Snake, Laticauda semifasciata.- Chemical and Pharmacological Characterization of Toxic Polypeptides from Four Elapidae Venoms.- Toxic Proteins in Cobra Venom Specifically Active on Arthropods.- Some Biological Properties of Two Tritiated Snake Neurotoxins.- Cationic Groups and Biological Activity of Cobrotoxin.- Cytocidal Activity of Cytotoxin from Indian Cobra Venom and Its Derivatives Against Experimental Tumors.- A Protein from Scorpion Venom Toxic to Crustaceans.- Enzymatic Radioiodination of Animal Toxins to Very High Specific Radioactivity.- Structure-Function Relationships of Scorpion Neurotoxins.- Fractionation of Sakishima-habu (Trimeresurus elegans) Venom and Lethal, Hemorrhagic and Edema-Forming Activities of the Fractions.- Some Physical and Biochemical Characteristics of HF2, One of the Hemorrhagic Factors in the Venom of Bothrops jararaca.- An Approach to the Physiological Mechanisms Involved in Hemorrhage: Snake Venom Hemorrhagic Principles as a Useful Analytical Tool.- Factors in the Blood Serum of Vipera palaestinae Neutralizing Toxic Fractions of its Venom.- Purification and Biological Properties of a Coagulant Protein from the Venom of Vipera russellii.- Characterization of the Coagulant Activity of the Venom of Aglyphous rhabdophis tigrinm Sndkt.- The Use of Snake Venoms in Coagulation Research and Therapy.- The Hemagglutinating Activity of Trimeresurus okinavensis Venom.- Phospholipase A from Formosan Cobra (Naja naja atra) Venom.- Action of Phospholipase A from Black Mamba (Dendroaspis polylepis) Venom of the Phospholipids of Human Blood.- Studies on the Effect of Trimeresurus flavoviridis Venom on Serum Ammonia and Phospholipid Level.- Proteases of Agkistrodon piscivorus leucostoma Venom.- Nucleolytic Enzymes of the Venom of Crotalus adamanteus.- Snake Venom ADPase.- Further Purification, Inhibitory Spectrum, and Some Kinetic Properties of Protease Inhibitor in Bee Venom.- Antimicrobial Activity of Alkaloids from Amphibian Venoms and Effects on the Ultrastructure of Yeast Cells.- The Toxic and Antitoxic Factors Derived from the Skin Secretion of the Flatfish Pardachinis marmoratus (Soleidae).- Separation of Grammistins A1 and A2 from a Soapfish Pogonoperca punctata.- Some Chemical Properties of the Skin Toxin in Coral Gobies Gobiodon spp.- Pharmacologically Active Amines in a Turban Shell, Turbo argyrostoma.- II Biochemistry (Plants).- Some Aspects of the Mechanism of Anticancer Activities of Abrin and Ricin.- Hemolysins in a Green Alga Ulva pertusa.- Occurrence of a Toxic Blue-Green Alga Inducing Skin Dermatitis in Okinawa.- Studies on the Mechanism of Action of Prymnesium Toxin toward Membranes.- III. Biochemistry (Microbes).- Mutation in ?-Phage Genome Affecting Diphtheria Toxin Structural Gene and Toxin Yield.- Two Antigenically Active, Complementary Polypeptide Fragments of Tetanus Neurotoxin.- Molecular Structure of Clostridium botulinum Toxins.- Factors Influencing the Production of a-Toxin (Phospholipase C) by Clostridium perfringens.- Complementation in Toxin Production between Mutants of Two Groups of Gostridium perfringens.- Purification and Characterization of a-Toxin (Phospholipase C) of Clostridium perfringens.- Studies on the Mode of Action of Phospholipases on Mammalian Erythrocytes.- Chemical Structure and Biochemical Action of Staphlococcal a-Toxin.- Streptokinase (SK) and Its Reactive Protein Separated from Human Plasma.- Cytolytic Substance Produced by Flavobacterium aquatile B5X.- Further Studies on Characterization and Biological Activities of an Enteropathogenic Toxin of Vibrio parahaemolyticus.- The Biological Properties of the Protein Moiety of Endotoxin of Pseudomonas aeruginosa.- Study on in Vivo Cytotoxicity Caused by Endotoxin Injection.- Histamine Hypersensitivity in Mice Induced by Bacterial Endotoxins.- The C
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