This thesis uses the tools of quantum information science to uncover fascinating new insights about the intersection of quantum theory and relativity. It is divided into three self-contained parts, the first of which employs detector models to investigate how the information content of quantum fields depends on spacetime curvature and global spacetime topology. The behavior of Unruh-DeWitt detectors on curved spacetimes are investigated, following which these detectors are used to probe the vacuum state of a scalar field in various topologies. This leads to a generalization of the entanglement harvesting protocol involving detectors in arbitrary curved spacetimes admitting a Wightman function. The second part extends the theory of quantum reference frames to those associated with noncompact groups. Motivated by the pursuit of a relational relativistic quantum theory where the group of reference frames is the Poincaré group, the author then generalizes a communication protocol between two parties lacking a common reference frame to the scenario where the group of transformations of their reference frame is a one-dimensional noncompact Lie group. Finally, the third part, inspired by theories of quantum gravity, generalizes the conditional probability interpretation of time, a proposed mechanism for time to emerge from a fundamentally timeless Universe. While the conditional probability interpretation of time is based upon conditioning a solution to the Wheeler-DeWitt equation on a subsystem of the universe that acts a clock, the author extends this approach to include an interaction between the system being used as a clock and a system whose evolution the clock is tracking.

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