图书简介
The aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions.
Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments.
The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered.
Key Features:
○ Differs from books in embryology in that it emphasizes roles of gene and gene regulation
○ It also discusses insight into development based on analyses of etiology of birth defects
Section I: Genome Architecture; Gene Regulations; Epigentics; Chromatin; Modification; Multiprotein Complexes; Transcription Factors; Stem Cell Biology; Gene Targeting; Mitochondria; Cilia; Programmed Cell DeathSection II: Organ Development Brain; Face; Bone; Extra-cellular Matrix; Sex Determination; Heart; Liver and Pancreas; Kidney; Lung; Abdominal Wall and Gastro-intestinal Tract; Section III: Growth Abnormalities; Environmental Factors; Genetic Syndromes Associated with Abnormal Growth or Tumor Development
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