图书简介
In the thirty years since its discovery by Terje Lomo and Tim Bliss, the phenomenon known as Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. LTP refers to a form of synaptic activity thought to play a central role in learning and memory. This volume presents a state of the art account of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.
T Bliss, G Collingridge & R Morris: Introduction; Foreword by Colin Blakemore; History; 1 P Andersen: A prelude to long-term potentiation; 2 T Lomo: The discovery of long-term potentiation; 3 T Bliss: A journey from neocortex to hippocampus; 4 G Lynch: Long-term potentiation in the Eocene; 5 B McNaughton: Long-term potentiation, cooperativity and Hebb’s cell assemblies: a personal history; 6 G Collingridge: The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation; 7 R Morris: Long-term potentiation and memory; Induction; 8 M Bear: Bidirectional synaptic plasticity: from theory to reality; 9 Z Bortolotto, S Lauri, J Isaac & G Collingridge: Kainate receptors and the induction of mossy fibre long-term potentiation; 10 D Johnston, B Christie, A Frick, R Gray, D Hoffman, L Schexnayder, S Watanabe & L-L Yuan: Active dendrites, potassium channels and synaptic plasticity; Expression; 11 M Errington, P Galley & T Bliss: Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode; 12 T Hosokawa, M Ohta, T Saito & A Fine: Imaging spatio-temporal patterns of long-term potentiation in mouse hippocampus; 13 S Choi, J Klingauf & R Tsien: Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation; 14 R Malinow: AMPA receptor trafficking and long-term potentiation; 15 F Duprat, M Daw, W Lim, G Collingridge & J Isaac: GluR2 protein-protein interactions and the reulation of AMPA receptors during synaptic plasticity; 16 R Nicoll: Expression mechanisms underlying long-term potentiation: a postsynaptic view; 17 D Kullmann: Silent synapses: what are they telling us about long-term potentiation?; Persistence; 18 W Abraham: How long will long-term potentiation last?; 19 K Harris, J Fiala & L Ostroff: Structural changes at dendritic spine synapses during long-term potentiation; 20 E Schuman & S Murase: Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions; 21 C Pittenger & E Kandel: In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus; Function; 22 C Barnes: Long-term potentiation and the ageing brain; 23 R Morris, E Moser, G Riedel, S Martin, J Sandin, M Day and C O’Carroll: Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory; 24 S Tonegawa, K Nakazawa & M Wilson: Genetic neuroscience of mammalian learning and memory; 25 G Hedou & I Mansuy: Inducible molecular switches for the study of long-term potentiation; 26 B Bozon, A Kelly, S Josselyn, A Silva, S Davis & S Laroche: MAPK, CREB and zif268 are all required for the consolidation of recognition memory; New Directions; 27 M Thomas & R Malenka: Synaptic plasticity in the mesolimbic dopamine system; 28 M Rowan, I Klyubin, W Cullen & R Anwyl: Synaptic plasticity in animal models of early Alzheimer’s disease; 29 J Lisman: Long-term potentiation: outstanding questions and attempted synthesis
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