图书简介

Hers: Foreword; Platt and Walkley: Preface; Malm: Prologue; Section I: Overview of Lysosomes and Storage Diseases; 1 Maxfield and Mukherjee: The endosomal-lysosomal system; 2 Platt and Walkley: Lysosomal defects and storage; 3 Wraith: Clinical aspects and diagnosis; Section II: Molecular Mechanisms of Storage; 4 Winchester: Primary defects in lysosomal enzymes; 5 von Figura et al: Defects in lysosomal enzyme modification for catalytic activity; 6 Hasilik and Lemansky: Defects in lysosomal enzyme trafficking; 7 d’Azzo: Defects in lysosomal enzyme protection: galactosialidosis; 8 Sandhoff and Kolter: Defects in activator proteins and other soluble proteins of the lysosome; 9 Ioannou: Defects in transmembrane proteins; Section III: Model Systems and Pathophysiological Mechanisms; 10 Pearce: Simple non-mammalian systems; 11 Hopwood et al: Spontaneous and engineered mammalian storage disease models; 12 Walkley: Pathogenic cascades and brain dysfunction; Section IV: Treatment of Storage Diseases; 13 Neufeld: Enzyme replacement therapy; 14 Dobrenis: Cell-mediated delivery systems; 15 Platt and Butters: Inhibition of substrate synthesis: a pharmacological approach for glycosphingolipid storage disease therapy; 16 Sands: Gene therapy

Trade Policy 买家须知